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NMDA 1 Receptor antibody (Splice Variant N1)

NMDA R1 Reactivity: Human, Rat, Mouse, Dog, Non-Human Primate, Chicken, Xenopus laevis WB, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372678
  • Target See all NMDA 1 Receptor (NMDA R1) Antibodies
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Binding Specificity
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Splice Variant N1
    Reactivity
    Human, Rat, Mouse, Dog, Non-Human Primate, Chicken, Xenopus laevis
    Host
    • 18
    • 5
    Rabbit
    Clonality
    • 18
    • 5
    Polyclonal
    Conjugate
    • 23
    This NMDA 1 Receptor antibody is un-conjugated
    Application
    • 18
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody recognizes the ~120k NR1 subunit, N1 splice variant insert protein of the NMDA Receptor. It Does not recognize NR1 subunits of the NMDA Receptor that do not contain the N1 insert.
    Cross-Reactivity (Details)
    Species reactivity (expected):Canine, Chicken, Human, Xenopus and non-Human Primates.
    Species reactivity (tested):Mouse and Rat.
    Purification
    Affinity Chromatography.
    Immunogen
    Peptide from the NR1 subunit, N1 splice variant insert of Rat NMDA Receptor.
    Isotype
    IgG
    Top Product
    Discover our top product NMDA R1 Primary Antibody
  • Application Notes
    Western blot: 1/1000. Immunohistochemistry on Frozen Sections: 1/1000-1/2000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in 50 μL PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.
    Buffer
    5 mM Ammonium Bicarbonate.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Target
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Alternative Name
    NMDA Receptor 1 (NMDA R1 Products)
    Synonyms
    CG2902 antibody, DMNMDAR1 antibody, DNMDAR-I antibody, DNmdar antibody, DmelNmdar1 antibody, Dmel\\CG2902 antibody, DrNR1 antibody, NMDA antibody, NMDA R1 antibody, NMDAR1 antibody, NMdar1 antibody, NR1 antibody, NRI antibody, Nmdar antibody, dNR1 antibody, dnmdar-I antibody, nmr antibody, NMDA receptor 1 antibody, Nmdar1 antibody
    Background
    The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.Synonyms: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1
    Gene ID
    24408
    NCBI Accession
    NP_058706
    UniProt
    P35439
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