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MAGEA3 antibody (C-Term)

MAGEA3 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB2084 unconjugated
Catalog No. ABIN390107
  • Target See all MAGEA3 Antibodies
    MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))
    Binding Specificity
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 283-314, C-Term
    Reactivity
    • 40
    • 1
    • 1
    Human
    Host
    • 27
    • 12
    • 1
    Rabbit
    Clonality
    • 29
    • 10
    • 1
    Polyclonal
    Conjugate
    • 25
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAGEA3 antibody is un-conjugated
    Application
    • 29
    • 19
    • 17
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.
    Clone
    RB2084
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Curioni-Fontecedro, Knights, Tinguely, Nuber, Schneider, Thomson, von Boehmer, Bossart, Pahlich, Gehring, Moch, Renner, Knuth, Zippelius: "MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma." in: Leukemia, Vol. 22, Issue 8, pp. 1646-8, (2008) (PubMed).

    Dubovsky, Albertini, McNeel: "MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 30, Issue 7, pp. 675-83, (2007) (PubMed).

    Kondo, Zhu, Asa, Ezzat: "The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4713-20, (2007) (PubMed).

  • Target
    MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))
    Alternative Name
    MAGEA3 (MAGEA3 Products)
    Synonyms
    CT1.3 antibody, HIP8 antibody, HYPD antibody, MAGE3 antibody, MAGEA6 antibody, Mage-a3 antibody, MAGEA3 antibody, MAGE family member A3 antibody, melanoma antigen, family A, 3 antibody, melanoma antigen family A, 3 antibody, MAGEA3 antibody, Magea3 antibody
    Background
    MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80 % sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
    Molecular Weight
    34747
    Gene ID
    4102
    NCBI Accession
    NP_005353
    UniProt
    P43357
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