EPHA1 antibody (C-Term)

Catalog No. ABIN391884

This anti-EPHA1 antibody is a Rabbit Polyclonal antibody detecting EPHA1 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for EPHA1 antibody (C-Term) (ABIN391884)

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPHA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1578

Product Details anti-EPHA1 Antibody

Binding Specificity: AA 913-943, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 913-943 amino acids from the C-terminal region of human EphA1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EPHA1 antibody (ABIN391884)

Wang, Hu, Tian, Zhou, Zhou, Wang: "Expression of EphA2 protein is positively associated with age, tumor size and Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 13374-80, (2016) (PubMed).

Wang, Liu, Cao, Zhang, Xu, Xu, Wang: "Expression of the EphA1 protein is associated with Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6821-7, (2015) (PubMed).

Dong, Wang, Sheng, Li, Ma, Wang, Zhang, Lu, Hu, Sugimura, Zhou: "Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 1, pp. 151-60, (2008) (PubMed).

Target Details for EPHA1

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Alternative Name: EphA1

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 108127

Gene ID: 2041

NCBI Accession: NP_005223

UniProt: P21709