THRB antibody (Isoform 1, Isoform beta-1, N-Term)

Catalog No. ABIN401449

Product Details anti-THRB Antibody

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Binding Specificity: Isoform 1, Isoform beta-1, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts with THRB protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein

Isotype: IgG

Application Details

Application Notes: ELISA: 1/200,000 - 1/220,000. Western Blot: 1/500 - 1/2,000. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.66 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB / ERBA2 (THRB Products)

Synonyms: C-ERBA-2 antibody, C-ERBA-BETA antibody, ERBA2 antibody, GRTH antibody, NR1A2 antibody, PRTH antibody, THR1 antibody, THRB1 antibody, THRB2 antibody, Nr1a2 antibody, T3R[b] antibody, T3Rbeta antibody, Thrb1 antibody, Thrb2 antibody, c-erbAbeta antibody, TR-beta antibody, TR[b]1 antibody, fj24f03 antibody, trb antibody, wu:fj24f03 antibody, CTR BETA 2 antibody, TR-BETA antibody, LOC734147 antibody, thrb antibody, THRB antibody, C-erba-beta antibody, RATT3REC antibody, T3rec antibody, TRbeta antibody, THR antibody, TRbeta1 antibody, thyroid hormone receptor beta antibody, thyroid hormone receptor, beta antibody, thyroid hormone receptor, beta S homeolog antibody, thyroid hormone receptor, beta L homeolog antibody, THRB antibody, Thrb antibody, thrb antibody, thrb.S antibody, thrb.L antibody

Background: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, THR1, Thyroid hormone receptor beta

Gene ID: 7068

NCBI Accession: NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound