FMR1 antibody (Internal Region)

Catalog No. ABIN452426

Product Details anti-FMR1 Antibody

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Binding Specificity: AA 116-130, Internal Region

Reactivity: Human, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This FMR1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: c-NPNKPATKDT FHKIK

Specificity: This antibody Recognizes FMR1.

Cross-Reactivity (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_002015.1. Genename: FMR1

Application Details

Application Notes: Peptide ELISA: 1/32000. Western blot: Approx 70Da band observed in lysates of cell lines HeLa and Jurkat(calculated MW of 71.2 kDa according to NP_002015.1). Recommended concentration: 0.3 -1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Alternative Name: FMR1 / FMRP (FMR1 Products)

Synonyms: AT24755 antibody, BcDNA:GM08679 antibody, CG6203 antibody, Dmel\\CG6203 antibody, EP(3)3517 antibody, FMR antibody, FMR1 antibody, FMRP antibody, FMRp antibody, FXR antibody, Fmrp antibody, cg6203 antibody, dFMR antibody, dFMR1 antibody, dFMRP antibody, dFXR antibody, dFXR1 antibody, dFXRP antibody, dFmr1 antibody, dFmrp antibody, dfmr antibody, dfmr1 antibody, dfxr antibody, dfxr1 antibody, dmfr1 antibody, fmr antibody, fmr1 antibody, FRAXA antibody, POF antibody, POF1 antibody, zFMR1 antibody, Fmr-1 antibody, CG6203 gene product from transcript CG6203-RC antibody, fragile X mental retardation 1 antibody, fragile X mental retardation syndrome 1 antibody, Fmr1 antibody, FMR1 antibody, fmr1 antibody

Background: FMRP is a RNA-binding protein that is associated to polysomes and may be involved in the transport of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.Synonyms: Fragile X mental retardation 1 protein, Protein FMR-1

Gene ID: 2332

NCBI Accession: NP_002015

UniProt: Q06787

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development