HACE1 antibody (Internal Region)
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- Target See all HACE1 Antibodies
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Xenopus laevis
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HACE1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- Reacts with human 102 kDa HACE1 protein
- Cross-Reactivity
- Mouse (Murine)
- Cross-Reactivity (Details)
- Cross react with mouse and Xenopus protein due to sequence homology.
- Purification
- Purified (protein A)
- Immunogen
- Synthetic peptide derived from internal domain ofhuman HACE1 protein.
- Top Product
- Discover our top product HACE1 Primary Antibody
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- Application Notes
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Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB: 1/1000 to 1/5000 IHC: 1/100 to 1/1000 - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Concentration
- 1 mg/mL
- Buffer
- Tris 0,1M, glycine 0,1M, sucrose 2 %
- Storage
- 4 °C/-20 °C
- Storage Comment
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 24 months
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- Target
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
- Alternative Name
- E3 Ubiquitin-Protein Ligase HACE1 (HACE1 Products)
- Synonyms
- HACE1 antibody, 1700042J16Rik antibody, A730034A22Rik antibody, BC025474 antibody, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 antibody, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog antibody, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 antibody, HACE1 antibody, hace1 antibody, hace1.L antibody, Hace1 antibody
- Background
- E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
- Gene ID
- 57531
- UniProt
- Q8IYU2
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