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BCR antibody
BCR
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-BCR Antibody
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Target
See all BCR Antibodies
BCR
(Breakpoint Cluster Region (BCR))
Reactivity
All reactivities for BCR antibodies
Human, Mouse, Rat
Host
All hosts for BCR antibodies
Rabbit
Clonality
All clonalities for BCR antibodies
Polyclonal
Conjugate
All conjugates for BCR antibodies
This BCR antibody is un-conjugated
Application
All applications for BCR antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Characteristics
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
Purification
Affinity purification
Immunogen
Recombinant protein of human BCR.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000 , IHC 1:50-1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freeze/thaw cycles.
Storage
-20 °C
Storage Comment
Store at -20°C.
Target Details for BCR
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Target
BCR
(Breakpoint Cluster Region (BCR))
Alternative Name
BCR (BCR Products )
Synonyms
si:dkey-83d9.7 antibody, zK83D9.7 antibody, BCR antibody, ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, 5133400C09Rik antibody, AI561783 antibody, AI853148 antibody, mKIAA3017 antibody, breakpoint cluster region antibody, BCR, RhoGEF and GTPase activating protein antibody, bcr antibody, BCR antibody, Bcr antibody
Gene ID
613
UniProt
P11274
Pathways
Regulation of Leukocyte Mediated Immunity , Platelet-derived growth Factor Receptor Signaling
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