RAD51C antibody

Catalog No. ABIN4952350

Product Details anti-RAD51C Antibody

Target: RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51C antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids IQHLQLIAEKHKGEEHRKALEDFTLDNILSH of human RAD51C were used as the immunogen for the RAD51C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RAD51C antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the RAD51C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for RAD51C

Target: RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))

Alternative Name: RAD51C (RAD51C Products)

Synonyms: RGD1563765 antibody, CG2412 antibody, Dm CG2412 antibody, Dmel\\CG2412 antibody, zgc:101596 antibody, RAD51C antibody, Rad51c antibody, ATRAD51C antibody, F4L23.21 antibody, RAS associated with diabetes protein 51C antibody, R51H3 antibody, Rad51l2 antibody, BROVCA3 antibody, FANCO antibody, RAD51L2 antibody, RAD51 paralog C antibody, Rad51 recombinase D antibody, Rad51 DNA recombinase 3 antibody, RAD51C protein antibody, RAD51 homolog C antibody, RAS associated with diabetes protein 51C antibody, RAD51C antibody, Rad51c antibody, Rad51D antibody, rad51c antibody

Background: RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene. This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. Ana this gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.

UniProt: O43502

Pathways: DNA Damage Repair