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ERCC2 antibody (C-Term)
ERCC2
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ERCC2 Antibody
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Target
See all ERCC2 Antibodies
ERCC2
(Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
Binding Specificity
All epitopes for ERCC2 antibodies
C-Term
Reactivity
All reactivities for ERCC2 antibodies
Human
Host
All hosts for ERCC2 antibodies
Rabbit
Clonality
All clonalities for ERCC2 antibodies
Polyclonal
Conjugate
All conjugates for ERCC2 antibodies
This ERCC2 antibody is un-conjugated
Application
All applications for ERCC2 antibodies
Western Blotting (WB), ELISA
Purification
Antigen affinity purified
Immunogen
This ERCC2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 687-722 amino acids from the C-terminal region of human ERCC2.
Isotype
Ig Fraction
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Discover our top product ERCC2 Primary Antibody
Alternatives
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Application Details
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Application Notes
Titration of the ERCC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the ERCC2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for ERCC2
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Target
ERCC2
(Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
Alternative Name
ERCC2 (ERCC2 Products )
Synonyms
COFS2 antibody, EM9 antibody, TTD antibody, XPD antibody, AA407812 antibody, AU020867 antibody, AW240756 antibody, CXPD antibody, Ercc-2 antibody, MGC89573 antibody, CG9433 antibody, DhR3 antibody, DhXPD antibody, DmXPD antibody, Dmel\\CG9433 antibody, ERCC2 antibody, XPD/ERCC2 antibody, l(2)SH2 2137 antibody, l(2)SH2137 antibody, xpd antibody, zgc:56365 antibody, ERCC excision repair 2, TFIIH core complex helicase subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody, excision repair cross-complementation group 2 antibody, Xeroderma pigmentosum D antibody, ERCC2 antibody, Ercc2 antibody, ercc2 antibody, Xpd antibody
Background
ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
UniProt
P18074
Pathways
DNA Damage Repair
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