ACVR2A antibody

Catalog No. ABIN498661

Product Details anti-ACVR2A Antibody

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2A antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of ACTRIIA protein. (region surrounding His59)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-ACVR2A antibody (ABIN498661)

Reichel, Farmer, Gmeiner, Walpurgis, Thevis: "Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting." in: Drug testing and analysis, Vol. 10, Issue 6, pp. 927-937, (2018) (PubMed).

Target Details for ACVR2A

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Alternative Name: Activin Receptor Type 2A (ACVR2A) (ACVR2A Products)

Synonyms: ACVR2 antibody, ACVR2A antibody, XSTK9 antibody, actrii antibody, acvr2 antibody, ACTRII antibody, Acvr2 antibody, rActR-II antibody, actr2a antibody, acvr2a antibody, wu:fa02e10 antibody, ActrIIa antibody, TactrII antibody, activin A receptor type 2A antibody, activin A receptor type 2A L homeolog antibody, activin A receptor type 2Aa antibody, activin receptor IIA antibody, ACVR2A antibody, acvr2a antibody, Acvr2a antibody, acvr2a.L antibody, acvr2aa antibody

Background: Members of the transforming growth factor beta superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (ACVR2A) or ACTRIIB (ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation and morphogenesis in a dose dependent manner.Synonyms: ACTR-IIA, ACTRIIA, Activin A receptor type IIA

Molecular Weight: approx. 48 kDa

Gene ID: 92

NCBI Accession: NP_001607

UniProt: P27037