IL16 antibody

Catalog No. ABIN498681

Product Details anti-IL16 Antibody

Target: IL16 (Interleukin 16 (IL16))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL16 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of IL-16 protein. (region surrounding Gly97)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL16

Target: IL16 (Interleukin 16 (IL16))

Alternative Name: Interleukin-16 / IL16 (IL16 Products)

Synonyms: IL16 antibody, LCF antibody, NIL16 antibody, PRIL16 antibody, prIL-16 antibody, mKIAA4048 antibody, IL-16 antibody, interleukin 16 antibody, IL16 antibody, Il16 antibody

Background: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, intiate signal transduction cascades that elicit physiological changes in their target cells. Interleukin-16, or IL-16, is a cytokine that has chemoattractant activity on CD4+ T lymphocytes. It has long been known that eosinophils and CD4+ T lymphocytes are recruited to sites of allergic inflammation, but the molecular mechanism was poorly understood. IL-16, also referred to as lymphocyte chemoattractant factor, is secreted by activated eosinophils as part of the allergic response along with RANTES, an additional cytokine. Once bound to its cognate receptor, CD4, IL-16 initiates a signal cascade that results in the activation of the PKC family.Synonyms: IL-16, LCF, Lymphocyte chemoattractant factor

Gene ID: 3603

NCBI Accession: NP_004504

UniProt: Q14005