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GATA1 antibody (pSer310)
GATA1
Reactivity: Human, Mouse, Rat
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-GATA1 Antibody
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Target
See all GATA1 Antibodies
GATA1
(GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1))
Binding Specificity
All epitopes for GATA1 antibodies
pSer310
Reactivity
All reactivities for GATA1 antibodies
Human, Mouse, Rat
Host
All hosts for GATA1 antibodies
Rabbit
Clonality
All clonalities for GATA1 antibodies
Polyclonal
Conjugate
All conjugates for GATA1 antibodies
This GATA1 antibody is un-conjugated
Application
All applications for GATA1 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects endogenous levels of p-GATA-1 protein only when phosphorylated at Ser310.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Discover our top product GATA1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for GATA1
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Target
GATA1
(GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1))
Alternative Name
GATA1 (GATA1 Products )
Synonyms
ERYF1 antibody, GATA-1 antibody, GF-1 antibody, GF1 antibody, NF-E1 antibody, NFE1 antibody, XLANP antibody, XLTDA antibody, XLTT antibody, Gata-1 antibody, Gf-1 antibody, eryf1 antibody, Eryf1 antibody, GATA1 antibody, gata-1 antibody, Gata1 antibody, si:dkeyp-77f7.5 antibody, gata1 antibody, gata1a-A antibody, xGATA-1 antibody, xgata1 antibody, XGATA-1B antibody, gata1b-A antibody, gta1 antibody, zg1 antibody, NF-E1a antibody, GATA binding protein 1 antibody, GATA binding protein 1 (globin transcription factor 1) antibody, amidase antibody, aspartyl/glutamyl-tRNA amidotransferase subunit A antibody, putative amidase antibody, GatA1 antibody, glutamyl-tRNA amidotransferase subunit A antibody, hematopietic transcription factor GATA-1 antibody, GATA binding protein 1b antibody, GATA binding protein 1 L homeolog antibody, GATA binding protein 1 S homeolog antibody, GATA binding protein 1a antibody, erythroid transcription factor antibody, GATA1 antibody, Gata1 antibody, gatA1 antibody, gata-1 antibody, gata1b antibody, gata1.L antibody, gata1.S antibody, gata1a antibody, LOC108348091 antibody
Background
GATA1 (Globin transcription factor 1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Acquired somatic mutations in GATA1 occur in virtually all children with Down's Syndrome, congenital transient myeloproliferative syndrome (TMD) and acute megakaryocytic leukemia.Synonyms: ERYF1, Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GF-1, GF1, NF-E1 DNA-binding protein
Molecular Weight
approx. 43 kDa
Gene ID
2623
NCBI Accession
NP_002040
UniProt
P15976
Pathways
Cellular Response to Molecule of Bacterial Origin
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