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NFKBIB antibody
NFKBIB
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NFKBIB Antibody
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Target
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NFKBIB
(NF-kappa-B inhibitor beta (NFKBIB))
Reactivity
All reactivities for NFKBIB antibodies
Human
Host
All hosts for NFKBIB antibodies
Rabbit
Clonality
All clonalities for NFKBIB antibodies
Polyclonal
Conjugate
All conjugates for NFKBIB antibodies
This NFKBIB antibody is un-conjugated
Application
All applications for NFKBIB antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of IkappaB-beta protein. (region surrounding Ala13)
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Application Details
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Application Notes
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for NFKBIB
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Target
NFKBIB
(NF-kappa-B inhibitor beta (NFKBIB))
Alternative Name
NFKBIB / IKBB (NFKBIB Products )
Synonyms
NFKBIB antibody, IKB-beta antibody, IKappaBbeta antibody, IkB antibody, IkBb antibody, IKBB antibody, TRIP9 antibody, NFKB inhibitor beta antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antibody, NFKBIB antibody, Nfkbib antibody
Background
Three major forms of IkappaB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkappaB-alpha and IkappaB-beta appear to be the major regulatory forms of IkappaB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkappaB and block nuclear import by masking the nuclear localization sequences of NFkappaB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkappaB. Immunoblotting easily detects the hyper-phosphorylated forms of IkappaB-alpha, but not phosphorylated IkappaB-beta.Synonyms: I-kappa-B-beta, IkB-B, IkB-beta, IkappaBbeta, NF-kappa-B inhibitor beta, TR-interacting protein 9, TRIP9, Thyroid receptor-interacting protein 9
Molecular Weight
approx. 37 kDa
Gene ID
4793
NCBI Accession
NP_001001716
UniProt
Q15653
Pathways
NF-kappaB Signaling , Activation of Innate immune Response , Maintenance of Protein Location , Toll-Like Receptors Cascades
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