PAK3 antibody

Catalog No. ABIN499020

Product Details anti-PAK3 Antibody

Target: PAK3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of PAKbeta protein. (region surrounding asn148)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PAK3

Target: PAK3

Alternative Name: PAK3 (PAK3 Products)

Synonyms: CDKN1A antibody, MRX30 antibody, MRX47 antibody, OPHN3 antibody, PAK3beta antibody, bPAK antibody, hPAK3 antibody, PAK-3 antibody, Pak65alpha antibody, Pak65beta antibody, Stk4 antibody, beta-PAK antibody, XPak3 antibody, bpak antibody, cdkn1a antibody, mrx30 antibody, mrx47 antibody, ophn3 antibody, pak3 antibody, pak3-A antibody, pak3beta antibody, p21 (RAC1) activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog antibody, PAK3 antibody, Pak3 antibody, pak3.L antibody

Background: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK3 forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. It may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.Synonyms: Beta-PAK, OPHN3, Oligophrenin-3, PAK 3, PAK beta, PAK-3, Serine/threonine-protein kinase PAK 3, p21-activated kinase 3

Molecular Weight: approx. 70 kDa

Gene ID: 5063

NCBI Accession: NP_001121645

UniProt: O75914