Growth Hormone Receptor antibody (AA 101-200) (AbBy Fluor® 680)

Catalog No. ABIN5003451

Product Details anti-Growth Hormone Receptor Antibody (AbBy Fluor® 680)

Target: Growth Hormone Receptor (GHR)

Binding Specificity: AA 101-200

Reactivity: Human, Mouse, Rat, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone Receptor antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Pig, Rat, Sheep

Predicted Reactivity: Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GHR

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: GHR (GHR Products)

Synonyms: GHBP antibody, AA986417 antibody, GHR/BP antibody, GHR antibody, ghr antibody, ghr.a antibody, zgc:162141 antibody, growth hormone receptor antibody, growth hormone receptor L homeolog antibody, growth hormone receptor a antibody, GHR antibody, Ghr antibody, ghr.L antibody, ghr antibody, ghra antibody

Background:

Synonyms: GHBP, Growth hormone receptor, GH receptor, Somatotropin receptor, GHR

Background: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

Gene ID: 2690

UniProt: P10912

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus