PD-L1 antibody (AA 18-227)
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- Target See all PD-L1 Antibodies
- PD-L1 (CD274 (PD-L1))
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Binding Specificity
- AA 18-227
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PD-L1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Protein A Chromatography
- Immunogen
- A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product PD-L1 Primary Antibody
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- Application Notes
- WB: 2-4 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Target
- PD-L1 (CD274 (PD-L1))
- Alternative Name
- PD-L1 / CD274 (PD-L1 Products)
- Synonyms
- B7-H antibody, B7H1 antibody, PD-L1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, A530045L16Rik antibody, B7h1 antibody, Pdcd1l1 antibody, Pdcd1lg1 antibody, Pdl1 antibody, RGD1566211 antibody, CD274 molecule antibody, CD274 antigen antibody, programmed cell death 1 ligand 2 antibody, CD274 antibody, Cd274 antibody, PDCD1LG2 antibody
- Background
- Programmed death ligand 1/PD-L1 (also called B7-H1 and CD274) is a T cell inhibitory molecule that is expressed on antigen presenting cells (APC) leading to T cell anergy and/or apoptosis upon ligation to its receptor Programmed death-1 (PD-1, CD279) on T cells. PD-L1 is expressed on tumor cells of a subset of breast cancer patients. It could also induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response.
- Molecular Weight
- 33 kDa
- Gene ID
- 29126
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
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