PD-L1 antibody (AA 18-227)
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- Target See all PD-L1 Antibodies
- PD-L1 (CD274 (PD-L1))
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Binding Specificity
- AA 18-227
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PD-L1 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Purification
- Protein G Chromatography
- Immunogen
- A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.
- Clone
- ABM4E54
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product PD-L1 Primary Antibody
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anti-CD274 (PD-L1) (C-Term) antibody
Verified PD-L1 Reactivity: Human WB, FACS, ELISA, IF Host: Goat Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 19-238) antibodyPD-L1 Reactivity: Human WB, FACS, IHC, ELISA, IF Host: Mouse Monoclonal 9B5F4 unconjugated
anti-CD274 (PD-L1) (AA 24-153) antibodyPD-L1 Reactivity: Human WB, FACS, IHC, ELISA, ICC, Neut Host: Mouse Monoclonal 6D9A2 unconjugated
anti-CD274 (PD-L1) (AA 39-191) antibodyPD-L1 Reactivity: Human, Mouse WB, FACS, IHC, ELISA, IF, Coat, StM Host: Mouse Monoclonal PDL1-2746 unconjugated
anti-CD274 (PD-L1) (AA 48-290) antibodyPD-L1 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-CD274 (PD-L1) (Extracellular Domain) antibodyPD-L1 Reactivity: Human IHC Host: Rabbit Monoclonal unconjugated
anti-CD274 (PD-L1) (AA 34-241) antibodyPD-L1 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 24-153) antibodyPD-L1 Reactivity: Human WB, FACS, IHC, ELISA, ICC Host: Mouse Monoclonal 7D2A10 unconjugated
anti-CD274 (PD-L1) (C-Term) antibodyKO Validated PD-L1 Reactivity: Human WB, FACS, ICC, IF, IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-CD274 (PD-L1) (AA 19-238) antibodyPD-L1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 0.5-1 μg/mL, IHC-5-10 μg/mL, FACS: 1-2 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Target
- PD-L1 (CD274 (PD-L1))
- Alternative Name
- PDL1 (PD-L1 Products)
- Synonyms
- B7-H antibody, B7H1 antibody, PD-L1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, A530045L16Rik antibody, B7h1 antibody, Pdcd1l1 antibody, Pdcd1lg1 antibody, Pdl1 antibody, RGD1566211 antibody, CD274 molecule antibody, CD274 antigen antibody, programmed cell death 1 ligand 2 antibody, CD274 antibody, Cd274 antibody, PDCD1LG2 antibody
- Background
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
- Molecular Weight
- 19 kDa
- Gene ID
- 29126
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
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