CLEC9A antibody (AA 15-218)

Catalog No. ABIN5027446

Product Details anti-CLEC9A Antibody

Target: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Binding Specificity: AA 15-218

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC9A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein G Chromatography

Immunogen: A partial length recombinant protein ( a.a 15-218) of CLEC9A was used as the immunogen for this antibody.

Clone: ABM23H8

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CLEC9A

Target: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Alternative Name: ClEC9A (CLEC9A Products)

Synonyms: 9830005G06Rik antibody, DNGR-1 antibody, DNGR1 antibody, UNQ9341 antibody, RGD1562513 antibody, C-type lectin domain family 9, member a antibody, C-type lectin domain containing 9A antibody, C-type lectin domain family 9, member A antibody, Clec9a antibody, CLEC9A antibody

Background: CLEC9A is a C-type lectin receptor involved in the sensing and presentation of antigens derived from necrotic cells. It is expressed on the surface of the mouse and human dendritic cell subsets specialized for the uptake and processing of material from dead cells. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. It possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase and can induce proinflammatory cytokine production. CLEC9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.

Molecular Weight: 44 kDa

Gene ID: 283420

UniProt: Q6UXN8