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RANKL antibody (AA 15-206)
TNFSF11
Reactivity: Human
WB, FACS
Host: Mouse
Monoclonal
ABM10D2
unconjugated
Product Details anti-RANKL Antibody
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Target
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RANKL (TNFSF11)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
Binding Specificity
All epitopes for RANKL antibodies
AA 15-206
Reactivity
All reactivities for RANKL antibodies
Human
Host
All hosts for RANKL antibodies
Mouse
Clonality
All clonalities for RANKL antibodies
Monoclonal
Conjugate
All conjugates for RANKL antibodies
This RANKL antibody is un-conjugated
Application
All applications for RANKL antibodies
Western Blotting (WB), Flow Cytometry (FACS)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant protein (a.a 15-206) of OPG was used as the immunogen for this antibody.
Clone
ABM10D2
Isotype
IgG1 kappa
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Discover our top product TNFSF11 Primary Antibody
Alternatives
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 210-317) antibody
TNFSF11
Reactivity: Human, Mouse, Rat, Rabbit
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
WB: 4-6 μg/mL, FACS: 0.5-1 μg/10^6
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for RANKL
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Target
RANKL (TNFSF11)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
Alternative Name
OPG (TNFSF11 Products )
Synonyms
CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNFSF11 antibody, Ly109l antibody, OPG antibody, Trance antibody, cd254 antibody, odf antibody, opgl antibody, optb2 antibody, rankl antibody, sodf antibody, tnfsf11 antibody, trance antibody, TNF superfamily member 11 antibody, tumor necrosis factor (ligand) superfamily, member 11 antibody, TNF receptor superfamily member 11b antibody, TNF superfamily member 11 L homeolog antibody, TNFSF11 antibody, Tnfsf11 antibody, TNFRSF11B antibody, tnfsf11.L antibody
Background
OPG (Osteoprotegerin) belongs to the TNF receptor super-family and is implicated in bone remodeling and in the atherosclerotic process. This molecule acts as a decoy receptor for the RANKL (Receptor Activator of Nuclear Factor-KappaB Ligand), inhibiting binding of RANKL to its receptor, RANK. OPG acts as a soluble neutralizing receptor of TRAIL (TNF-Related Apoptosis-Inducing Ligand), an anti-inflammatory molecule with anti-atherosclerotic properties. Mostly implicated in bone remodeling, the RANK/RANKL/OPG axis is involved in immune and vascular system. OPG has been associated with increased risk of atherosclerotic disease in the general population. OPG has also been associated with increased pulse wave velocity, progression of arterial calcification and with mortality in both end-stage renal failure patients as well as the general population.
Molecular Weight
44 kDa
Gene ID
4982
UniProt
O00300
Pathways
NF-kappaB Signaling
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