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CD20 antibody
MS4A1
Reactivity: Human
FACS, WB
Host: Mouse
Monoclonal
ABM46C7
unconjugated
Product Details anti-CD20 Antibody
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Target
See all CD20 (MS4A1) Antibodies
CD20 (MS4A1)
(Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))
Reactivity
All reactivities for CD20 antibodies
Human
Host
All hosts for CD20 antibodies
Mouse
Clonality
All clonalities for CD20 antibodies
Monoclonal
Conjugate
All conjugates for CD20 antibodies
This CD20 antibody is un-conjugated
Application
All applications for CD20 antibodies
Flow Cytometry (FACS), Western Blotting (WB)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant protein corresponding to extra cellular domain of CD20 was used as the immunogen for this antibody.
Clone
ABM46C7
Isotype
IgG2b kappa
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Discover our top product MS4A1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 2-4 μg/mL FACS : 0.5 μg / 10^6 cells
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for CD20
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Target
CD20 (MS4A1)
(Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))
Alternative Name
CD20 (MS4A1 Products )
Synonyms
B1 antibody, Bp35 antibody, CD20 antibody, CVID5 antibody, LEU-16 antibody, MS4A2 antibody, S7 antibody, AA960661 antibody, Cd20 antibody, Ly-44 antibody, Ms4a2 antibody, MS4A1 antibody, bp35 antibody, cd20 antibody, ms4a2 antibody, leu-16 antibody, ms4a4c antibody, cd20-like antibody, membrane spanning 4-domains A1 antibody, membrane-spanning 4-domains, subfamily A, member 1 antibody, B-lymphocyte antigen CD20 antibody, MS4A1 antibody, Ms4a1 antibody, ms4a1 antibody, LOC101694281 antibody
Background
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surfacemake CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
Molecular Weight
32 kDa
Gene ID
931
UniProt
P11836
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