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PD-L1 antibody (AA 13-224)
PD-L1
Reactivity: Human
WB, FACS, IHC
Host: Mouse
Monoclonal
ABM5F25
unconjugated
Product Details anti-PD-L1 Antibody
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Target
See all PD-L1 Antibodies
PD-L1
(CD274 (PD-L1))
Binding Specificity
All epitopes for PD-L1 antibodies
AA 13-224
Reactivity
All reactivities for PD-L1 antibodies
Human
Host
All hosts for PD-L1 antibodies
Mouse
Clonality
All clonalities for PD-L1 antibodies
Monoclonal
Conjugate
All conjugates for PD-L1 antibodies
This PD-L1 antibody is un-conjugated
Application
All applications for PD-L1 antibodies
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.
Clone
ABM5F25
Isotype
IgG2b kappa
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Alternatives
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Application Details
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Application Notes
FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL, IHC: 5-10 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
References for anti-PD-L1 antibody (ABIN5027497)
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Faruk, Ibrahim, Aminu, Adamu, Abdullahi, Suleiman, Rafindadi, Mohammed, Iliyasu, Idoko, Saidu, Randawa, Musa, Ntekim, Shah, Abubakar, Adoke, Manko, Awasum : "Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin. " in: PLoS ONE , Vol. 16 , Issue 1 , pp. e0245581 , (2021 ) (PubMed ).
Target Details for PD-L1
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Target
PD-L1
(CD274 (PD-L1))
Alternative Name
PDL-1 (PD-L1 Products )
Synonyms
B7-H antibody, B7H1 antibody, PD-L1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, A530045L16Rik antibody, B7h1 antibody, Pdcd1l1 antibody, Pdcd1lg1 antibody, Pdl1 antibody, RGD1566211 antibody, CD274 molecule antibody, CD274 antigen antibody, programmed cell death 1 ligand 2 antibody, CD274 antibody, Cd274 antibody, PDCD1LG2 antibody
Background
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
Molecular Weight
44 kDa
Gene ID
29126
UniProt
Q9NZQ7
Pathways
Cancer Immune Checkpoints
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