Survivin antibody

Catalog No. ABIN5027791

Product Details anti-Survivin Antibody

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Survivin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: Full length recombinant Survivin protein was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: Survivin (BIRC5 Products)

Synonyms: AP14 antibody, API4 antibody, EPR-1 antibody, AAC-11 antibody, Api4 antibody, TIAP antibody, survivin40 antibody, bir5a antibody, survivin antibody, BIR1 antibody, Su2 antibody, XBIR1 antibody, XSurvivin1 antibody, Xsvv1 antibody, api4 antibody, bir1-A antibody, epr-1 antibody, svv1 antibody, xSurvivin antibody, xsurv antibody, Su1 antibody, birc5.2 antibody, svv2 antibody, xSurvivin2 antibody, bir5b antibody, SIX antibody, birc5.2-a antibody, birc5.2-b antibody, baculoviral IAP repeat containing 5 antibody, baculoviral IAP repeat-containing 5 antibody, baculoviral IAP repeat containing 5a antibody, baculoviral IAP repeat-containing 5, gene 1 L homeolog antibody, baculoviral IAP repeat containing 5 L homeolog antibody, baculoviral IAP repeat containing 5b antibody, baculoviral IAP repeat containing 5 S homeolog antibody, BIRC5 antibody, Birc5 antibody, birc5a antibody, birc5.1.L antibody, birc5.2.L antibody, birc5b antibody, birc5.2.S antibody

Background: Survivin is the smallest mammalian member of the IAP (Inhibitor-Of-Apoptosis) gene family. It regulates two essential cellular processes, inhibits apoptosis and promotes cell proliferation. Survivin also plays a main role in cancer progression because it prevents apoptosis by inhibition of caspase 3 and caspase 7, and by regulating the G2 and M phases of the cell cycle. Overexpression of survivin is associated with neoplasia and metastasis. Survivin might be used as a biomarker and a primary chemotherapeutic target for the detection and treatment of gastrointestinal tract cancer, especially esophageal, gastric, and colon cancers.

Molecular Weight: 19 kDa

Gene ID: 332

UniProt: O15392

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding