RAGE antibody

Catalog No. ABIN533488

Product Details anti-RAGE Antibody

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAGE antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: Mouse monoclonal antibody raised against recombinant AGER.

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: Recombinant protein corresponding to human AGER.

Clone: 1C5

Isotype: IgG1

Application Details

Application Notes: Western Blot (0.1 μg/mL)
Immunocytochemistry (1 μg/mL)
ELISA (0.1 μg/mL)
Flow Cyt (1 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.1 % proclin, 2.0 % Block Ace)

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-RAGE antibody (ABIN533488)

Koyama, Yamamoto, Nishizawa: "RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases." in: Molecular medicine (Cambridge, Mass.), Vol. 13, Issue 11-12, pp. 625-35, (2007) (PubMed).

Riuzzi, Sorci, Donato et al.: "The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE ..." in: The Journal of biological chemistry, Vol. 281, Issue 12, pp. 8242-53, (2006) (PubMed).

Inomata, Takahashi, Nagata, Yamada, Shiratori, Tanaka, Satoh, Saitoh, Sato, Abe: "Acute lung injury as an adverse event of gefitinib." in: Anti-cancer drugs, Vol. 15, Issue 5, pp. 461-7, (2004) (PubMed).

Yonekura, Yamamoto, Sakurai, Petrova, Abedin, Li, Yasui, Takeuchi, Makita, Takasawa, Okamoto, Watanabe, Yamamoto: "Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury." in: The Biochemical journal, Vol. 370, Issue Pt 3, pp. 1097-109, (2003) (PubMed).

Taguchi, Blood, del Toro, Canet, Lee, Qu, Tanji, Lu, Lalla, Fu, Hofmann, Kislinger, Ingram, Lu, Tanaka, Hori, Ogawa, Stern, Schmidt: "Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases." in: Nature, Vol. 405, Issue 6784, pp. 354-60, (2000) (PubMed).

Target Details for RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Alternative Name: RAGE / AGER (AGER Products)

Synonyms: RAGE antibody, AGER antibody, advanced glycosylation end-product specific receptor antibody, advanced glycosylation end product-specific receptor antibody, MAPK/MAK/MRK overlapping kinase antibody, AGER antibody, Ager antibody, LOC719012 antibody

Gene ID: 177

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins