Integrin Alpha2b antibody (Biotin)

Catalog No. ABIN536003

Product Details anti-Integrin Alpha2b Antibody (Biotin)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against native ITGA2B.

Specificity: This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 KDa) and GPIIb beta (light chain, 23 KDa). CD41 is mainly expressed on platelets and megakaryocytes.

Cross-Reactivity: Human

Immunogen: Native purified ITGA2B from leukocytes of a patient suffering from a LGL-type leukemia.

Clone: MEM-06

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (1:200)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.

References for anti-Integrin Alpha2b antibody (Biotin) (ABIN536003)

Zhang, Varas, Stadtfeld, Heck, Faust, Graf: "CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation." in: Experimental hematology, Vol. 35, Issue 3, pp. 490-499, (2007) (PubMed).

Ferkowicz, Starr, Xie, Li, Johnson, Shelley, Morrison, Yoder: "CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo." in: Development (Cambridge, England), Vol. 130, Issue 18, pp. 4393-403, (2003) (PubMed).

Mitjavila-Garcia, Cailleret, Godin, Nogueira, Cohen-Solal, Schiavon, Lecluse, Le Pesteur, Lagrue, Vainchenker: "Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells." in: Development (Cambridge, England), Vol. 129, Issue 8, pp. 2003-13, (2002) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 / ITGA2B (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Gene ID: 3674

Pathways: Integrin Complex