The optimal working dilution should be determined by the end user.
Restrictions
For Research Use only
Format
Liquid
Buffer
In PBS (0.05 % BSA, 0.05 % sodium azide)
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Frullanti, Colombo, Falvella, Galvan, Noci, De Cecco, Incarbone, Alloisio, Santambrogio, Nosotti, Tosi, Pastorino, Dragani: "Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue." in: International journal of cancer. Journal international du cancer, Vol. 131, Issue 5, pp. E643-8, (2012) (PubMed).
Wang, Wei, Zhu, Zhang, Shen, Xing, OKeefe, Chen: "Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10742-8, (2007) (PubMed).
Yoshiura, Ohtsuka, Takenaka, Nagahara, Yoshikawa, Kageyama: "Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 27, pp. 11292-7, (2007) (PubMed).
Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, (2006) (PubMed).
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: "Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation." in: Toxicology, Vol. 226, Issue 2-3, pp. 131-42, (2006) (PubMed).
Target
SMAD6
(SMAD, Mothers Against DPP Homolog 6 (SMAD6))