NPC1L1 antibody (AA 1000-1100)

Catalog No. ABIN540363

Product Details anti-NPC1L1 Antibody

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Binding Specificity: AA 1000-1100

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of Npc1l1.

Specificity: This antibody is specific to NPC1L1 protein.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide corresponding to amino acids 1000-1100 of rat Npc1l1.

Application Details

Application Notes: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-NPC1L1 antibody (ABIN540363)

Infante, Abi-Mosleh, Radhakrishnan, Dale, Brown, Goldstein: "Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein." in: The Journal of biological chemistry, Vol. 283, Issue 2, pp. 1052-63, (2008) (PubMed).

Montoudis, Seidman, Boudreau, Beaulieu, Menard, Elchebly, Mailhot, Sane, Lambert, Delvin, Levy: "Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake." in: Journal of lipid research, Vol. 49, Issue 5, pp. 961-72, (2008) (PubMed).

Liu, Mani, Davis, Sarrafzadegan, Kavathas, Mani: "Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance." in: Circulation research, Vol. 103, Issue 11, pp. 1280-8, (2008) (PubMed).

Nauli, Nassir, Zheng, Yang, Lo, Vonlehmden, Lee, Jandacek, Abumrad, Tso: "CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine." in: Gastroenterology, Vol. 131, Issue 4, pp. 1197-207, (2006) (PubMed).

Target Details for NPC1L1

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Alternative Name: Npc1l1 (NPC1L1 Products)

Synonyms: NPC1L1 antibody, 9130221N23Rik antibody, Gm243 antibody, NPC11L1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, NPC1 like 1 antibody, NPC1-like 1 antibody, NPC1L1 antibody, npc1l1 antibody, Npc1l1 antibody

Gene ID: 432367