INSIG1 antibody (AA 1-100)

Catalog No. ABIN540703

Product Details anti-INSIG1 Antibody

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of INSIG1.

Specificity: This antibody is specific to Insig1 but not Insig2.

Cross-Reactivity: Human

Immunogen: A synthetic peptide corresponding to amino acids 1-100 of human INSIG1.

Application Details

Application Notes: Western Blot (2 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (30 % glycerol, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-INSIG1 antibody (ABIN540703)

De Marinis, Martini, Trentalance, Pallottini: "Sex differences in hepatic regulation of cholesterol homeostasis." in: The Journal of endocrinology, Vol. 198, Issue 3, pp. 635-43, (2008) (PubMed).

Gong, Lee, Lee, Goldstein, Brown, Ye: "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake." in: Cell metabolism, Vol. 3, Issue 1, pp. 15-24, (2006) (PubMed).

Engelking, Liang, Hammer, Takaishi, Kuriyama, Evers, Li, Horton, Goldstein, Brown: "Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins." in: The Journal of clinical investigation, Vol. 115, Issue 9, pp. 2489-98, (2005) (PubMed).

Target Details for INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Alternative Name: INSIG1 (INSIG1 Products)

Synonyms: cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody

Gene ID: 3638

Pathways: ER-Nucleus Signaling