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ATP7B antibody (Middle Region)
ATP7B
Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ATP7B Antibody
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Target
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ATP7B
(ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))
Binding Specificity
All epitopes for ATP7B antibodies
Middle Region
Reactivity
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
Host
All hosts for ATP7B antibodies
Rabbit
Clonality
All clonalities for ATP7B antibodies
Polyclonal
Conjugate
All conjugates for ATP7B antibodies
This ATP7B antibody is un-conjugated
Application
All applications for ATP7B antibodies
Western Blotting (WB)
Sequence
IIMSTLTLVV WIVIGFIDFG VVQRYFPNPN KHISQTEVII RFAFQTSITV
Predicted Reactivity
Dog: 82%, Guinea Pig: 82%, Horse: 82%, Human: 100%, Mouse: 91%, Rabbit: 92%, Rat: 91%
Characteristics
This is a rabbit polyclonal antibody against ATP7B. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ATP7B
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for ATP7B
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Target
ATP7B
(ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))
Alternative Name
ATP7B (ATP7B Products )
Synonyms
PWD antibody, WC1 antibody, WD antibody, WND antibody, Atp7a antibody, tx antibody, Hts antibody, PINA antibody, Wd antibody, ATP7B antibody, ATPase copper transporting beta antibody, ATPase, Cu++ transporting, beta polypeptide antibody, ATPase, Cu++ transporting, beta polypeptide (Wilson disease) antibody, copper-transporting ATPase 2 antibody, ATP7B antibody, Atp7b antibody, atp7b antibody, LOC592143 antibody
Background
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). Alias Symbols: WD, PWD, WC1, WND Protein Size: 676
Gene ID
540
NCBI Accession
NM_000053 , NP_000044
UniProt
P35670
Pathways
Transition Metal Ion Homeostasis , Ribonucleoside Biosynthetic Process
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