PCGF2 antibody (Middle Region)

Catalog No. ABIN5514708

Product Details anti-PCGF2 Antibody

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCGF2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EQEKGALSDD EIVSLSIEFY EGARDRDEKK GPLENGDGDK EKTGVRFLRC

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCGF2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCGF2

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Alternative Name: PCGF2 (PCGF2 Products)

Synonyms: ZNF144 antibody, PCGF2 antibody, MEL-18 antibody, RNF110 antibody, Mel18 antibody, Rnf110 antibody, Zfp144 antibody, mel-18 antibody, polycomb group ring finger 2 antibody, PCGF2 antibody, Pcgf2 antibody

Background: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Alias Symbols: MEL-18, RNF110, ZNF144,

Protein Size: 344

Gene ID: 7703

NCBI Accession: NM_007144, NP_009075

UniProt: P35227

Pathways: Chromatin Binding