MKRN1 antibody (C-Term)

Catalog No. ABIN5514960

Product Details anti-MKRN1 Antibody

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MKRN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SRYRAQRRNH FWELIEEREN SNPFDNDEEE VVTFELGEML LMLLAAGGDD

Characteristics: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MKRN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MKRN1

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Alternative Name: MKRN1 (MKRN1 Products)

Synonyms: MKRN1 antibody, MGC84269 antibody, mkrn1 antibody, Makorin-1 antibody, RNF61 antibody, RFP antibody, makorin ring finger protein 1 antibody, E3 ubiquitin-protein ligase makorin-1 antibody, makorin ring finger protein 1 S homeolog antibody, makorin, ring finger protein, 1 antibody, MKRN1 antibody, LOC100393879 antibody, mkrn1.S antibody, Mkrn1 antibody

Background: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: RNF61

Protein Size: 482

Gene ID: 23608

NCBI Accession: NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding