SAFB antibody (Middle Region)

Catalog No. ABIN5515130

Product Details anti-SAFB Antibody

Target: SAFB (Scaffold Attachment Factor B (SAFB))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAFB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TELHGKMISV EKAKNEPVGK KTSDKRDSDG KKEKSSNSDR STNLKRDDKC

Characteristics: This is a rabbit polyclonal antibody against SAFB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SAFB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SAFB

Target: SAFB (Scaffold Attachment Factor B (SAFB))

Alternative Name: SAFB1 (SAFB Products)

Synonyms: HAP antibody, HET antibody, SAF-B1 antibody, SAFB1 antibody, 3110021E02Rik antibody, 5330423C17Rik antibody, AU018122 antibody, D18386 antibody, E130307D12 antibody, zgc:55387 antibody, wu:fb40a03 antibody, wu:fd42g06 antibody, SAFB2 antibody, SAFB antibody, scaffold attachment factor B antibody, scaffold attachment factor B S homeolog antibody, SAFB-like transcription modulator antibody, Scaffold attachment factor B antibody, SAFB antibody, Safb antibody, safb antibody, safb.S antibody, LOC5570070 antibody, CpipJ_CPIJ017179 antibody, Bm1_49330 antibody, LOAG_00080 antibody

Background: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: SAFB, HAP, HET, SAFB1,

Protein Interaction Partner: SUMO3, STAU1, UBC, LGR4, SUMO1, EED, rev, TP63, IL7R, CSNK2A1, MAP1LC3A, TP53BP1, TRMT112, TMOD2, RBMX, NCSTN, ACIN1, SMU1, U2AF2, CPSF6, GCN1L1, UTP14A, USP39, SAP18, VTN, U2AF1, TPBG, SURF4, SON, SRSF7, PRKAR1A, ABCC1, LAMP2, SEPT7, AK2, ACAT1, ZC3H18,

Protein Size: 848

Gene ID: 6294

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway