UNC13B antibody (Middle Region)

Catalog No. ABIN5515349

Product Details anti-UNC13B Antibody

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SYDLDYPERR AISPTSSSRY GSSCNVSQGS SQLSELDQYH EQDDDHRETD

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UNC13B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UNC13B

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Alternative Name: UNC13B (UNC13B Products)

Synonyms: MUNC13 antibody, UNC13 antibody, Unc13h2 antibody, UNC13B antibody, Munc13-2 antibody, Munc13-1 antibody, Unc13a antibody, Unc13h1 antibody, unc-13 homolog B antibody, unc-13 homolog B (C. elegans) antibody, UNC13B antibody, Unc13b antibody

Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Alias Symbols: UNC13, MUNC13, Unc13h2

Protein Size: 1591

Gene ID: 10497

NCBI Accession: NM_006377, NP_006368

UniProt: O14795

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis