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DHCR7 antibody (N-Term)
DHCR7
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DHCR7 Antibody
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Target
See all DHCR7 Antibodies
DHCR7
(7-Dehydrocholesterol Reductase (DHCR7))
Binding Specificity
All epitopes for DHCR7 antibodies
N-Term
Reactivity
All reactivities for DHCR7 antibodies
Human
Host
All hosts for DHCR7 antibodies
Rabbit
Clonality
All clonalities for DHCR7 antibodies
Polyclonal
Conjugate
All conjugates for DHCR7 antibodies
This DHCR7 antibody is un-conjugated
Application
All applications for DHCR7 antibodies
Western Blotting (WB)
Sequence
AAKSQPNIPK AKSLDGVTND RTASQGQWGR AWEVDWFSLA SVIFLLLFAP
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DHCR7
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for DHCR7
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Target
DHCR7
(7-Dehydrocholesterol Reductase (DHCR7))
Alternative Name
DHCR7 (DHCR7 Products )
Synonyms
7-Dhcr antibody, Xdhcr7 antibody, MGC64361 antibody, slos antibody, 7-STEROL DELTA7 REDUCTASE antibody, 7RED antibody, DELTA5 antibody, DWARF 5 antibody, F11F12.21 antibody, F11F12_21 antibody, LE antibody, LEPIDA antibody, PA antibody, PARVA antibody, ST7R antibody, STEROL DELTA7 REDUCTASE antibody, DKFZp468C1911 antibody, AA409147 antibody, SLOS antibody, xdhcr7 antibody, 7-dehydrocholesterol reductase antibody, 7-dehydrocholesterol reductase L homeolog antibody, Ergosterol biosynthesis ERG4/ERG24 family antibody, DHCR7 antibody, dhcr7 antibody, dhcr7.L antibody, DWF5 antibody, PAAG_04766 antibody, PITG_13128 antibody, VDBG_05423 antibody, MGYG_00712 antibody, TERG_00580 antibody, Dhcr7 antibody
Background
This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein. Alias Symbols: SLOS Protein Size: 475
Gene ID
1717
NCBI Accession
NM_001163817 , NP_001157289
UniProt
Q9UBM7
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