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PABPN1 antibody (C-Term)
PABPN1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PABPN1 Antibody
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Target
See all PABPN1 Antibodies
PABPN1
(Poly A Binding Protein Nuclear 1 (PABPN1))
Binding Specificity
All epitopes for PABPN1 antibodies
C-Term
Reactivity
All reactivities for PABPN1 antibodies
Human
Host
All hosts for PABPN1 antibodies
Rabbit
Clonality
All clonalities for PABPN1 antibodies
Polyclonal
Conjugate
All conjugates for PABPN1 antibodies
This PABPN1 antibody is un-conjugated
Application
All applications for PABPN1 antibodies
Western Blotting (WB)
Sequence
NRPGISTTDR GFPRARYRAR TTNYNSSRSR FYSGFNSRPR GRVYRGRARA
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human PABPN1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for PABPN1
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Target
PABPN1
(Poly A Binding Protein Nuclear 1 (PABPN1))
Alternative Name
PABPN1 (PABPN1 Products )
Synonyms
OPMD antibody, PAB2 antibody, PABII antibody, PABP-2 antibody, PABP2 antibody, Pabp3 antibody, mPABII antibody, ARABIDOPSIS POLY(A) BINDING 2 antibody, ATPAB2 antibody, F28A23.130 antibody, F28A23_130 antibody, POLY(A) BINDING PROTEIN 2 antibody, POLY(A)-BINDING PROTEIN 2 antibody, poly(A) binding protein 2 antibody, opmd antibody, pab2 antibody, pabp2 antibody, pabpii antibody, pabpn1 antibody, Pabpn1 antibody, Poly(A)-binding protein 2 antibody, fb19c03 antibody, wu:fb17e03 antibody, wu:fb18c06 antibody, wu:fb19c03 antibody, zgc:85979 antibody, zgc:92452 antibody, poly(A) binding protein nuclear 1 antibody, poly(A) binding protein, nuclear 1 antibody, poly(A) binding protein 2 antibody, poly(A) binding protein, nuclear 1 S homeolog antibody, poly(A) binding protein, nuclear 1 L homeolog antibody, polyadenylate-binding protein 2 antibody, poly(A) binding protein Pab2 antibody, PABPN1 antibody, Pabpn1 antibody, PAB2 antibody, pabpn1.S antibody, pabpn1.L antibody, LOC100728725 antibody, pab2 antibody, pabpn1 antibody
Background
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. Alias Symbols: OPMD, PAB2, PABII, PABP2, PABP-2, Protein Size: 333
Gene ID
8106
NCBI Accession
NM_001199839 , NP_004634
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