CNTNAP2 antibody (Middle Region)

Catalog No. ABIN5515940

Product Details anti-CNTNAP2 Antibody

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNTNAP2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRYNFQAPAT NARDSSSRVD NAPDQQNSHP DLAQEEIRFS FSTTKAPCIL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CNTNAP2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Alternative Name: CNTNAP2 (CNTNAP2 Products)

Synonyms: AUTS15 antibody, CASPR2 antibody, CDFE antibody, NRXN4 antibody, PTHSL1 antibody, 5430425M22Rik antibody, Caspr2 antibody, mKIAA0868 antibody, CASPR antibody, MGC145769 antibody, MGC147944 antibody, MGC147981 antibody, contactin associated protein like 2 antibody, contactin associated protein-like 2 antibody, contactin associated protein like 2b antibody, CNTNAP2 antibody, Cntnap2 antibody, cntnap2b antibody, cntnap2 antibody

Background: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5 % of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation

Alias Symbols: CDFE, NRXN4, AUTS15, CASPR2, PTHSL1

Protein Size: 328

Gene ID: 26047

NCBI Accession: NM_014141, NP_054860

UniProt: A0A0J9YYA0