AKR1C1 antibody (Middle Region)

Catalog No. ABIN5515960

Product Details anti-AKR1C1 Antibody

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KIADGSVKRE DIFYTSKLWC NSHRPELVRP ALERSLKNLQ LDYVDLYLIH

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AKR1C1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AKR1C1

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Alternative Name: AKR1C1 (DDH Products)

Synonyms: 2-ALPHA-HSD antibody, 20-ALPHA-HSD antibody, C9 antibody, DD1 antibody, DD1/DD2 antibody, DDH antibody, DDH1 antibody, H-37 antibody, HAKRC antibody, HBAB antibody, MBAB antibody, aldo-keto reductase family 1 member C1 antibody, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) antibody, AKR1C1 antibody

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Alias Symbols: C9, DD1, DDH, DDH1, H-37, HBAB, MBAB, HAKRC, DD1/DD2, 2-ALPHA-HSD, 20-ALPHA-HSD

Protein Size: 323

Gene ID: 1645

NCBI Accession: NP_001344

UniProt: Q04828

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process