PDE6A antibody (Middle Region)

Catalog No. ABIN5516136

Product Details anti-PDE6A Antibody

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YTVRAFLNCD RYSVGLLDMT KQKEFFDVWP VLMGEVPPYS GPRTPDGREI

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PDE6A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Alternative Name: PDE6A (PDE6A Products)

Synonyms: si:bz1d10.3 antibody, si:rp71-1d10.3 antibody, CGPR-A antibody, PDEA antibody, RP43 antibody, Pdea antibody, nmf282 antibody, phosphodiesterase 6A, cGMP-specific, rod, alpha antibody, phosphodiesterase 6A antibody, pde6a antibody, PDE6A antibody, Pde6a antibody

Background: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Alias Symbols: PDEA, RP43, CGPR-A

Protein Size: 167

Gene ID: 5145

NCBI Accession: NM_000440, NP_000431

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction