USP19 antibody (Middle Region)

Catalog No. ABIN5516193

Product Details anti-USP19 Antibody

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP19 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SQFTGYAQHD AQEFMAFLLD GLHEDLNRIQ NKPYTETVDS DGRPDEVVAE

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human USP19

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for USP19

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Alternative Name: USP19 (USP19 Products)

Synonyms: wu:fc26a05 antibody, si:dkey-32e6.9 antibody, USP19 antibody, MGC145127 antibody, ZMYND9 antibody, 8430421I07Rik antibody, AI047774 antibody, Zmynd9 antibody, ubiquitin specific peptidase 19 antibody, universal stress protein antibody, ubiquitin carboxyl-terminal hydrolase 19 antibody, usp19 antibody, USP19 antibody, RR_RS18085 antibody, PTRG_09611 antibody, Usp19 antibody

Background: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

Alias Symbols: ZMYND9

Protein Size: 1419

Gene ID: 10869

NCBI Accession: NM_001199160, NP_001186089