WAPAL antibody (Middle Region)

Catalog No. ABIN5516204

Product Details anti-WAPAL Antibody

Target: WAPAL (Wings Apart-Like Protein Homolog (WAPAL))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WAPAL antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KSKKDVKLEF FGFEDHETGG DEGGSGSSNY KIKYFGFDDL SESEDDEDDD

Characteristics: This is a rabbit polyclonal antibody against WAPL. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human WAPL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for WAPAL

Target: WAPAL (Wings Apart-Like Protein Homolog (WAPAL))

Alternative Name: WAPL (WAPAL Products)

Synonyms: RGD1308960 antibody, FOE antibody, KIAA0261 antibody, WAPL antibody, 2410073G16 antibody, A530089A20Rik antibody, BC037674 antibody, mKIAA0261 antibody, mWAPL antibody, WAPL cohesin release factor antibody, Wapl antibody, WAPL antibody, wapl antibody

Background: WAPL is a regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. It is involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. It couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Alias Symbols: WAPAL, FOE, KIAA0261, WAPL,

Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, XRN1, PDS5A, SMC3, VCP, VPS16, WRAP53, USP15, USP10, NSMCE2, ELAVL1, SUMO2, RAD21, ARAP1, Stag2, WAPAL, PDS5B, STAG1, SMC1A, SRRM1,

Protein Size: 1190

Gene ID: 23063

NCBI Accession: NP_055860

UniProt: Q7Z5K2

Pathways: Chromatin Binding