Chitotriosidase 1 antibody (C-Term)

Catalog No. ABIN5516322

Product Details anti-Chitotriosidase 1 Antibody

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chitotriosidase 1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GTPELEVPKP GQPSEPEHGP SPGQDTFCQG KADGLYPNPR ERSSFYSCAA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CHIT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Chitotriosidase 1

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Alternative Name: CHIT1 (CHIT1 Products)

Synonyms: CHI3 antibody, CHIT antibody, CHITD antibody, CHIT1 antibody, chio antibody, 2300002L19Rik antibody, chitinase 1 antibody, chitinase 1 (chitotriosidase) antibody, CHIT1 antibody, chit1 antibody, Chit1 antibody

Background: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

Alias Symbols: CHI3, CHIT, CHITD

Protein Size: 466

Gene ID: 1118

NCBI Accession: NM_001256125, NP_001243054

UniProt: Q13231