14-3-3 sigma/SFN antibody (N-Term)

Catalog No. ABIN5516411

Product Details anti-14-3-3 sigma/SFN Antibody

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 14-3-3 sigma/SFN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IEQKSNEEGS EEKGPEVREY REKVETELQG VCDTVLGLLD SHLIKEAGDA

Characteristics: This is a rabbit polyclonal antibody against SFN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SFN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for 14-3-3 sigma/SFN

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Alternative Name: SFN (SFN Products)

Synonyms: YWHAS antibody, Er antibody, Mme1 antibody, Ywhas antibody, stratifin antibody, SFN antibody, Sfn antibody

Background: SFN is a p53-regulated inhibitor of G2/M progression. It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. It may also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

Alias Symbols: SFN, HME1,

Protein Interaction Partner: FAM9B, RAB3IP, LONRF1, CCDC102B, ZC2HC1C, DTL, FAM53C, MKRN3, FOXO4, MAGEA1, CCNH, SIK3, ZFYVE19, YWHAZ, VCL, UBE2V1, SNRPF, UBE2R2, PAK2, G6PD, TARDBP, EGFR, BAD, MARK3, HDAC7, HDAC5, HDAC4, RAF1, CDC25C, MST1R, ABL1, HNRNPD, ATF2, TRIM32, COPS6, UBC, TP

Protein Size: 248

Gene ID: 2810

NCBI Accession: NP_006133

UniProt: P31947

Pathways: p53 Signaling, Myometrial Relaxation and Contraction