APC antibody (Middle Region)

Catalog No. ABIN5516442

Product Details anti-APC Antibody

Target: APC (Adenomatous Polyposis Coli (APC))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SETFDNIDNL SPKASHRSKQ RHKQSLYGDY VFDTNRHDDN RSDNFNTGNM

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC (APC Products)

Synonyms: dp2 antibody, dp3 antibody, fap antibody, fpc antibody, xapc antibody, dp2.5 antibody, AI047805 antibody, AU020952 antibody, AW124434 antibody, CC1 antibody, Min antibody, mAPC antibody, BTPS2 antibody, DP2 antibody, DP2.5 antibody, DP3 antibody, GS antibody, PPP1R46 antibody, RATAPC antibody, APC1 antibody, APC, WNT signaling pathway regulator antibody, adenomatous polyposis coli antibody, adenomatous polyposis coli protein, putative antibody, adenomatosis polyposis coli antibody, adenomatous polyposis coli L homeolog antibody, APC antibody, apc antibody, Smp_139190 antibody, Apc antibody, apc.L antibody

Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Alias Symbols: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46

Protein Size: 1304

Gene ID: 324

NCBI Accession: NM_000038, NP_000029

UniProt: E9PFT7

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization