LAIR1 antibody (C-Term)

Catalog No. ABIN5516675

Product Details anti-LAIR1 Antibody

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAIR1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HRQNQIKQGP PRSKDEEQKP QQRPDLAVDV LERTADKATV NGLPEKDRET

Characteristics: This is a rabbit polyclonal antibody against LAIR1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LAIR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LAIR1

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Alternative Name: LAIR1 (LAIR1 Products)

Synonyms: 5133400O11Rik antibody, BB115266 antibody, D7Bwg0421e antibody, Lair-1 antibody, mLair-1 antibody, CD305 antibody, LAIR-1 antibody, leukocyte-associated Ig-like receptor 1 antibody, leukocyte associated immunoglobulin like receptor 1 antibody, leukocyte-associated immunoglobulin-like receptor 1 antibody, Lair1 antibody, LAIR1 antibody

Background: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.

Alias Symbols: LAIR1, CD305,

Protein Interaction Partner: LAIR1, APP, UBC, PTPN6, PTPN11, CSK,

Protein Size: 287

Gene ID: 3903

UniProt: Q6GTX8