Nyctalopin antibody (Middle Region)

Catalog No. ABIN5517443

Product Details anti-Nyctalopin Antibody

Target: Nyctalopin (NYX)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nyctalopin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GSGRVTDVPC ASPGSVAGLD LSQVTFGRSS DGLCVDPEEL NLTTSSPGPS

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NYX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Nyctalopin

Target: Nyctalopin (NYX)

Alternative Name: NYX (NYX Products)

Synonyms: MGC84276 antibody, CLRP antibody, CSNB1 antibody, CSNB1A antibody, CSNB4 antibody, NBM1 antibody, CLNP antibody, nob antibody, RGD1561300 antibody, nyctalopin antibody, nyctalopin L homeolog antibody, uncharacterized LOC491837 antibody, NYX antibody, nyx.L antibody, LOC491837 antibody, nyx antibody, Nyx antibody

Background: The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB.

Alias Symbols: CLRP, NBM1, CSNB1, CSNB4, CSNB1A

Protein Size: 481

Gene ID: 60506

NCBI Accession: NM_022567, NP_072089

UniProt: Q9GZU5