DUSP8 antibody (C-Term)

Catalog No. ABIN5531052

Product Details anti-DUSP8 Antibody

Target: DUSP8 (Dual Specificity Phosphatase 8 (DUSP8))

Binding Specificity: AA 456-487, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DUSP8

Target: DUSP8 (Dual Specificity Phosphatase 8 (DUSP8))

Alternative Name: DUSP8 (DUSP8 Products)

Synonyms: zgc:77593 antibody, C11orf81 antibody, HB5 antibody, HVH-5 antibody, HVH8 antibody, 5530400B01Rik antibody, AI593498 antibody, Nttp1 antibody, Hb5 antibody, M3/6 antibody, DUSP8 antibody, dual specificity phosphatase 8 antibody, dual specificity phosphatase 8a antibody, dual specificity protein phosphatase 8 antibody, DUSP8 antibody, dusp8 antibody, dusp8a antibody, DSP8 antibody, Dusp8 antibody, LOC615727 antibody

Background: DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.

Molecular Weight: 66 kDa

Gene ID: 1850

UniProt: Q13202