This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Immunogen
This CYP2C8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-105 amino acids from the N-terminal region of human CYP2C8.
CYP2C8
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
For WB starting dilution is: 1:1000
Restrictions
For Research Use only
Format
Liquid
Concentration
2 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
CYP2C8
(Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))
CPC8 antibody, CYPIIC8 antibody, MP-12/MP-20 antibody, CYP2C74 antibody, cpc8 antibody, cyp2c8 antibody, cypiic8 antibody, mp-12/mp-20 antibody, cytochrome P450 family 2 subfamily C member 8 antibody, Cytochrome P450 2C8 antibody, cytochrome P450, family 2, subfamily C, polypeptide 8 antibody, cytochrome P450 family 2 subfamily C member 8 S homeolog antibody, CYP2C8 antibody, CTN_0597 antibody, cyp2c8.1.S antibody, cyp2c8.1 antibody
Background
CYP2C8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol.