IREB2 antibody (AA 201-230)

Catalog No. ABIN5534428

Product Details anti-IREB2 Antibody

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Binding Specificity: AA 201-230

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IREB2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

For FACS starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IREB2

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Alternative Name: IREB2 (IREB2 Products)

Synonyms: IREB2 antibody, im:7153062 antibody, DKFZp468N047 antibody, D9Ertd85e antibody, Irp2 antibody, ACO3 antibody, IRP2 antibody, IRP2AD antibody, IREBP2 antibody, iron responsive element binding protein 2 antibody, iron-responsive element binding protein 2 antibody, iron responsive element binding protein 2 L homeolog antibody, IREB2 antibody, ireb2 antibody, Ireb2 antibody, ireb2.L antibody

Background: IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Molecular Weight: 105 kDa

Gene ID: 3658

UniProt: P48200

Pathways: Transition Metal Ion Homeostasis