SEPSECS antibody (C-Term)

Catalog No. ABIN5535961

Product Details anti-SEPSECS Antibody

Target: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (Selenocysteine) tRNA Synthase (SEPSECS))

Binding Specificity: AA 444-474, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEPSECS antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SEPSECS

Target: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (Selenocysteine) tRNA Synthase (SEPSECS))

Alternative Name: SEPSECS (SEPSECS Products)

Synonyms: LP antibody, PCH2D antibody, SLA antibody, SLA/LP antibody, 9130208G10 antibody, AA986712 antibody, D5Ertd135e antibody, SecS antibody, sla/lpl antibody, zgc:55980 antibody, sepsecs antibody, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase antibody, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase L homeolog antibody, SEPSECS antibody, Sepsecs antibody, sepsecs antibody, sepsecs.L antibody

Target Type: Antibody

Background: The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP, MIM 165060) by seryl-tRNA synthetase (SARS, MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK, MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).

Molecular Weight: 56 kDa

Gene ID: 51091

UniProt: Q9HD40

Pathways: SARS-CoV-2 Protein Interactome