ERN2 antibody (N-Term)

Catalog No. ABIN5536056

Product Details anti-ERN2 Antibody

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Binding Specificity: AA 39-72, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERN2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ERN2

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Alternative Name: ERN2 (ERN2 Products)

Synonyms: Ire1beta antibody, ire1b antibody, Ern1 antibody, Ire1 antibody, Ire1b antibody, IRE1-BETA antibody, IRE1b antibody, endoplasmic reticulum to nucleus signaling 2 antibody, endoplasmic reticulum (ER) to nucleus signalling 2 antibody, ERN2 antibody, ern2 antibody, Ern2 antibody

Background: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Molecular Weight: 102 kDa

Gene ID: 10595

UniProt: Q76MJ5