FBXW12 antibody (C-Term)

Catalog No. ABIN5536790

Product Details anti-FBXW12 Antibody

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Binding Specificity: AA 291-320, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW12 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXW12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human FBXW12.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FBXW12

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Alternative Name: FBXW12 (FBXW12 Products)

Synonyms: FBW12 antibody, FBXO12 antibody, FBXO35 antibody, RGD1307859 antibody, F-box and WD repeat domain containing 12 antibody, FBXW12 antibody, Fbxw12 antibody

Background: Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Molecular Weight: 53 kDa

Gene ID: 285231

UniProt: Q6X9E4